Epicenter concerns brassy, beautiful Amanda Foster, a down-on-her-luck Los Angeles detective who's been assigned to protect a mobster-turned-State's-Witness, Nick Constantine, from the mob. On the night of the assignment, the city is rocked by a devastating earthquake, forcing Amanda and Nick to fight their way through the ravaged city streets while being pursued by ruthless assassins and corrupt cops.
Undercover cop Doyle is working on a serial killer case that's left a trail of dead transvestites. Then, moonlighting as a private eye, Doyle and his girlfriend are hired by a rich young man to find his sister. The search leads to her mysterious uncle, and the possibility of becoming the killer's next victim.